Mesenchymal stem cells support proliferation and terminal differentiation of B cells.

نویسندگان

  • Yue Ru Ji
  • Zhou Xin Yang
  • Zhi-Bo Han
  • Lei Meng
  • Lu Liang
  • Xiao Ming Feng
  • Shao Guang Yang
  • Ying Chi
  • Dan Dan Chen
  • You Wei Wang
  • Zhong Chao Han
چکیده

BACKGROUND Mesenchymal stem cells (MSC) play important roles in modulating the activities of T lymphocytes, dendritic cells and natural killer cells. These immunoregulatory properties of MSC suggest their therapeutic potential in autoimmune diseases. However, the effects of MSC on B cells are still poorly understood. The present study was designed to investigate the interaction between MSC and B cells both in vitro and in vivo, and to determine the possible mechanism of action. DESIGN AND METHOD The effect of human umbilical cord mesenchymal stem cells (UC-MSC) on proliferation and differentiation of B-cells were characterized in vitro, and we also tested the immunoregulatory properties of mouse bone marrow MSC (BM-MSC) on T cell dependent and independent antibody production in vivo in mice. RESULTS Treatment with human UC-MSC resulted in an increase of proliferation, differentiation of B cells into plasma cells and production of antibodies in vitro. Mouse BM-MSC significantly enhanced T cell dependent and independent antibodies production in vivo in mice. PGE2 partially mediated the immunosuppressive activity of human UC-MSC but IL-6 did not regulate this activity. CONCLUSION MSC promote proliferation and differentiation of B cells in vitro and in vivo partially through PGE2 but not IL-6.

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عنوان ژورنال:
  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

دوره 30 6  شماره 

صفحات  -

تاریخ انتشار 2012